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cd8 + t-cell ko mice  (Jackson Laboratory)

 
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    Jackson Laboratory cd8 + t-cell ko mice
    Compare NMI reinfection induced innate and adaptive cellular responses between PBS and different doses of primary NMI-infected mice. BALB/c mice were IP infected with PBS, 1 × 10 2 , 1 × 10 4 , or 1 × 10 5 GE of NMI bacteria. All dose of NMI-infected and PBS control mice were IP challenged with 1 × 10 7 GE of NMI bacteria at 35 days post primary NMI infection. In addition, naive BALB/c mice were used as uninfected normal mouse controls. The absolute cell numbers of macrophages plus monocytes, neutrophils, dendritic cells, B cells, <t>CD8</t> + T cells, and CD4 + T cells in the spleen were determined by flow cytometry and compared between PBS control and primary NMI-infected mice at 14 days after NMI reinfection. (A) , macrophages plus monocytes (CD11b + CD11c − Ly6G − ). (B) , neutrophils (CD11b + Ly6G + ). (C) , Dendritic cells (CD11c + ). (D) , B cells (CD19 + ). (E) , CD8 + T cells (CD3 + CD8 + ). (F) , CD4 + T cells (CD3 + CD4 + ). Data presented in each group are the averages with SD for four mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01 and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.
    Cd8 + T Cell Ko Mice, supplied by Jackson Laboratory, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cd8 + t-cell ko mice/product/Jackson Laboratory
    Average 90 stars, based on 1 article reviews
    cd8 + t-cell ko mice - by Bioz Stars, 2026-06
    90/100 stars

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    1) Product Images from "Coxiella burnetii Nine Mile phase I primary infection derived protective immunity against C. burnetii reinfection in mice depends on both B and T cells, but T cells play a critical role"

    Article Title: Coxiella burnetii Nine Mile phase I primary infection derived protective immunity against C. burnetii reinfection in mice depends on both B and T cells, but T cells play a critical role

    Journal: Frontiers in Immunology

    doi: 10.3389/fimmu.2024.1427822

    Compare NMI reinfection induced innate and adaptive cellular responses between PBS and different doses of primary NMI-infected mice. BALB/c mice were IP infected with PBS, 1 × 10 2 , 1 × 10 4 , or 1 × 10 5 GE of NMI bacteria. All dose of NMI-infected and PBS control mice were IP challenged with 1 × 10 7 GE of NMI bacteria at 35 days post primary NMI infection. In addition, naive BALB/c mice were used as uninfected normal mouse controls. The absolute cell numbers of macrophages plus monocytes, neutrophils, dendritic cells, B cells, CD8 + T cells, and CD4 + T cells in the spleen were determined by flow cytometry and compared between PBS control and primary NMI-infected mice at 14 days after NMI reinfection. (A) , macrophages plus monocytes (CD11b + CD11c − Ly6G − ). (B) , neutrophils (CD11b + Ly6G + ). (C) , Dendritic cells (CD11c + ). (D) , B cells (CD19 + ). (E) , CD8 + T cells (CD3 + CD8 + ). (F) , CD4 + T cells (CD3 + CD4 + ). Data presented in each group are the averages with SD for four mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01 and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.
    Figure Legend Snippet: Compare NMI reinfection induced innate and adaptive cellular responses between PBS and different doses of primary NMI-infected mice. BALB/c mice were IP infected with PBS, 1 × 10 2 , 1 × 10 4 , or 1 × 10 5 GE of NMI bacteria. All dose of NMI-infected and PBS control mice were IP challenged with 1 × 10 7 GE of NMI bacteria at 35 days post primary NMI infection. In addition, naive BALB/c mice were used as uninfected normal mouse controls. The absolute cell numbers of macrophages plus monocytes, neutrophils, dendritic cells, B cells, CD8 + T cells, and CD4 + T cells in the spleen were determined by flow cytometry and compared between PBS control and primary NMI-infected mice at 14 days after NMI reinfection. (A) , macrophages plus monocytes (CD11b + CD11c − Ly6G − ). (B) , neutrophils (CD11b + Ly6G + ). (C) , Dendritic cells (CD11c + ). (D) , B cells (CD19 + ). (E) , CD8 + T cells (CD3 + CD8 + ). (F) , CD4 + T cells (CD3 + CD4 + ). Data presented in each group are the averages with SD for four mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01 and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.

    Techniques Used: Infection, Bacteria, Control, Flow Cytometry

    The protective efficacy of primary NMI-infection induced protection against NMI reinfection in B cell, T cell, CD4 + T cell or CD8 + T cell deficient mice. C57BL/6J WT and B cell, T cell, CD4 + T cell or CD8 + T cell deficient mice were IP infected with 1 × 10 4 GE of NMI bacteria and challenged with 1 × 10 7 GE of NMI bacteria at 35 days post-primary NMI-infection. Additionally, naive WT mice were mock infected with PBS and served as controls. Splenomegaly and bacterial burden in the spleen were measured at 14 days post-challenge. (A) , Relative body weights (current body weight/day 0 body weight) were measured throughout the challenge period. (B) , Splenomegaly (% of spleen weight/body weight). (C) , bacterial burden in the spleen was determined by real-time qPCR and is expressed as log10 C . burnetii com1 gene copy numbers. Data presented in each group are the averages with SD for five mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01; ***P < 0.001; and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.
    Figure Legend Snippet: The protective efficacy of primary NMI-infection induced protection against NMI reinfection in B cell, T cell, CD4 + T cell or CD8 + T cell deficient mice. C57BL/6J WT and B cell, T cell, CD4 + T cell or CD8 + T cell deficient mice were IP infected with 1 × 10 4 GE of NMI bacteria and challenged with 1 × 10 7 GE of NMI bacteria at 35 days post-primary NMI-infection. Additionally, naive WT mice were mock infected with PBS and served as controls. Splenomegaly and bacterial burden in the spleen were measured at 14 days post-challenge. (A) , Relative body weights (current body weight/day 0 body weight) were measured throughout the challenge period. (B) , Splenomegaly (% of spleen weight/body weight). (C) , bacterial burden in the spleen was determined by real-time qPCR and is expressed as log10 C . burnetii com1 gene copy numbers. Data presented in each group are the averages with SD for five mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01; ***P < 0.001; and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.

    Techniques Used: Infection, Bacteria



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    cd8 + t-cell ko mice  (Jackson Laboratory)
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    Jackson Laboratory cd8 + t-cell ko mice
    Compare NMI reinfection induced innate and adaptive cellular responses between PBS and different doses of primary NMI-infected mice. BALB/c mice were IP infected with PBS, 1 × 10 2 , 1 × 10 4 , or 1 × 10 5 GE of NMI bacteria. All dose of NMI-infected and PBS control mice were IP challenged with 1 × 10 7 GE of NMI bacteria at 35 days post primary NMI infection. In addition, naive BALB/c mice were used as uninfected normal mouse controls. The absolute cell numbers of macrophages plus monocytes, neutrophils, dendritic cells, B cells, <t>CD8</t> + T cells, and CD4 + T cells in the spleen were determined by flow cytometry and compared between PBS control and primary NMI-infected mice at 14 days after NMI reinfection. (A) , macrophages plus monocytes (CD11b + CD11c − Ly6G − ). (B) , neutrophils (CD11b + Ly6G + ). (C) , Dendritic cells (CD11c + ). (D) , B cells (CD19 + ). (E) , CD8 + T cells (CD3 + CD8 + ). (F) , CD4 + T cells (CD3 + CD4 + ). Data presented in each group are the averages with SD for four mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01 and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.
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    cd8 t cell deficient mice (h-2kb/db ko) on a b6 background  (Taconic Biosciences)
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    Compare NMI reinfection induced innate and adaptive cellular responses between PBS and different doses of primary NMI-infected mice. BALB/c mice were IP infected with PBS, 1 × 10 2 , 1 × 10 4 , or 1 × 10 5 GE of NMI bacteria. All dose of NMI-infected and PBS control mice were IP challenged with 1 × 10 7 GE of NMI bacteria at 35 days post primary NMI infection. In addition, naive BALB/c mice were used as uninfected normal mouse controls. The absolute cell numbers of macrophages plus monocytes, neutrophils, dendritic cells, B cells, <t>CD8</t> + T cells, and CD4 + T cells in the spleen were determined by flow cytometry and compared between PBS control and primary NMI-infected mice at 14 days after NMI reinfection. (A) , macrophages plus monocytes (CD11b + CD11c − Ly6G − ). (B) , neutrophils (CD11b + Ly6G + ). (C) , Dendritic cells (CD11c + ). (D) , B cells (CD19 + ). (E) , CD8 + T cells (CD3 + CD8 + ). (F) , CD4 + T cells (CD3 + CD4 + ). Data presented in each group are the averages with SD for four mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01 and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.
    Cd8 T Cell Deficient Mice (H 2kb/Db Ko) On A B6 Background, supplied by Taconic Biosciences, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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    cd8 t cell deficient mice (h-2kb/db ko) on a b6 background - by Bioz Stars, 2026-06
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    Image Search Results


    Compare NMI reinfection induced innate and adaptive cellular responses between PBS and different doses of primary NMI-infected mice. BALB/c mice were IP infected with PBS, 1 × 10 2 , 1 × 10 4 , or 1 × 10 5 GE of NMI bacteria. All dose of NMI-infected and PBS control mice were IP challenged with 1 × 10 7 GE of NMI bacteria at 35 days post primary NMI infection. In addition, naive BALB/c mice were used as uninfected normal mouse controls. The absolute cell numbers of macrophages plus monocytes, neutrophils, dendritic cells, B cells, CD8 + T cells, and CD4 + T cells in the spleen were determined by flow cytometry and compared between PBS control and primary NMI-infected mice at 14 days after NMI reinfection. (A) , macrophages plus monocytes (CD11b + CD11c − Ly6G − ). (B) , neutrophils (CD11b + Ly6G + ). (C) , Dendritic cells (CD11c + ). (D) , B cells (CD19 + ). (E) , CD8 + T cells (CD3 + CD8 + ). (F) , CD4 + T cells (CD3 + CD4 + ). Data presented in each group are the averages with SD for four mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01 and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.

    Journal: Frontiers in Immunology

    Article Title: Coxiella burnetii Nine Mile phase I primary infection derived protective immunity against C. burnetii reinfection in mice depends on both B and T cells, but T cells play a critical role

    doi: 10.3389/fimmu.2024.1427822

    Figure Lengend Snippet: Compare NMI reinfection induced innate and adaptive cellular responses between PBS and different doses of primary NMI-infected mice. BALB/c mice were IP infected with PBS, 1 × 10 2 , 1 × 10 4 , or 1 × 10 5 GE of NMI bacteria. All dose of NMI-infected and PBS control mice were IP challenged with 1 × 10 7 GE of NMI bacteria at 35 days post primary NMI infection. In addition, naive BALB/c mice were used as uninfected normal mouse controls. The absolute cell numbers of macrophages plus monocytes, neutrophils, dendritic cells, B cells, CD8 + T cells, and CD4 + T cells in the spleen were determined by flow cytometry and compared between PBS control and primary NMI-infected mice at 14 days after NMI reinfection. (A) , macrophages plus monocytes (CD11b + CD11c − Ly6G − ). (B) , neutrophils (CD11b + Ly6G + ). (C) , Dendritic cells (CD11c + ). (D) , B cells (CD19 + ). (E) , CD8 + T cells (CD3 + CD8 + ). (F) , CD4 + T cells (CD3 + CD4 + ). Data presented in each group are the averages with SD for four mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01 and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.

    Article Snippet: BALB/c (Strain # 000651), C57BL/6 (Strain # 000664), B-cell KO ( Ighm tm1Cgn/J , strain # 002288) mice, T-cell KO ( Foxn1 nu , strain # 000819) mice, CD4 + T-cell KO ( Cd4 tm1Mak , strain # 002663) and CD8 + T-cell KO ( Cd8a tm1Mak , strain # 002665) mice were purchased from the Jackson Laboratory (Bar Harbor, ME).

    Techniques: Infection, Bacteria, Control, Flow Cytometry

    The protective efficacy of primary NMI-infection induced protection against NMI reinfection in B cell, T cell, CD4 + T cell or CD8 + T cell deficient mice. C57BL/6J WT and B cell, T cell, CD4 + T cell or CD8 + T cell deficient mice were IP infected with 1 × 10 4 GE of NMI bacteria and challenged with 1 × 10 7 GE of NMI bacteria at 35 days post-primary NMI-infection. Additionally, naive WT mice were mock infected with PBS and served as controls. Splenomegaly and bacterial burden in the spleen were measured at 14 days post-challenge. (A) , Relative body weights (current body weight/day 0 body weight) were measured throughout the challenge period. (B) , Splenomegaly (% of spleen weight/body weight). (C) , bacterial burden in the spleen was determined by real-time qPCR and is expressed as log10 C . burnetii com1 gene copy numbers. Data presented in each group are the averages with SD for five mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01; ***P < 0.001; and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.

    Journal: Frontiers in Immunology

    Article Title: Coxiella burnetii Nine Mile phase I primary infection derived protective immunity against C. burnetii reinfection in mice depends on both B and T cells, but T cells play a critical role

    doi: 10.3389/fimmu.2024.1427822

    Figure Lengend Snippet: The protective efficacy of primary NMI-infection induced protection against NMI reinfection in B cell, T cell, CD4 + T cell or CD8 + T cell deficient mice. C57BL/6J WT and B cell, T cell, CD4 + T cell or CD8 + T cell deficient mice were IP infected with 1 × 10 4 GE of NMI bacteria and challenged with 1 × 10 7 GE of NMI bacteria at 35 days post-primary NMI-infection. Additionally, naive WT mice were mock infected with PBS and served as controls. Splenomegaly and bacterial burden in the spleen were measured at 14 days post-challenge. (A) , Relative body weights (current body weight/day 0 body weight) were measured throughout the challenge period. (B) , Splenomegaly (% of spleen weight/body weight). (C) , bacterial burden in the spleen was determined by real-time qPCR and is expressed as log10 C . burnetii com1 gene copy numbers. Data presented in each group are the averages with SD for five mice, with error bars representing the SD from the means. *P < 0.05; **P < 0.01; ***P < 0.001; and ****P < 0.0001 were determined by one-way ANOVA with Tukey’s post-test.

    Article Snippet: BALB/c (Strain # 000651), C57BL/6 (Strain # 000664), B-cell KO ( Ighm tm1Cgn/J , strain # 002288) mice, T-cell KO ( Foxn1 nu , strain # 000819) mice, CD4 + T-cell KO ( Cd4 tm1Mak , strain # 002663) and CD8 + T-cell KO ( Cd8a tm1Mak , strain # 002665) mice were purchased from the Jackson Laboratory (Bar Harbor, ME).

    Techniques: Infection, Bacteria